Room: 305B, BMSB Office: 2609 6787 Email: yu-huang@cuhk.edu.hk

HUANG, Yu

Professor

B.Sc (1983) Shanghai First Medical College
M.Phil (1985) University of Cambridge
Ph. D (1988) University of Cambridge

Research Interests:

General fields:Vascular Physiology and Pharmacology, Ion Channels, Endothelium and Smooth Muscle

Specific fields:

(1) Vascular Action of Estrogen and Selective Estrogen Receptor Modulators
(2) Role of periadentitial adipose tissue in the regulation of vascular tone in obesity, diabetes and hypertension
(3) Role of Potassium, Second Messengers, and Endothelium-derived Factors in Regulation of Vascular Tone
(4) Hypotensive and antioxidant Actions of Biologically Active Components of Traditional Chinese Herbs and Natural Plants

Selected Publications:

1. TSANG SY, YAO XQ, CHAN HY, CHAN FL, LEUNG CSL, YUNG LM, AU CL, CHEN ZY, LAHER I & HUANG Y (2007) Tamoxifen and estrogen attenuates enhanced vascular tone induced by estrogen deficiency in rat carotid arteries. Biochemical Pharmacology 73(9):1330-1339.

2. LEUNG HS, YUNG LM, LEUNG FP, YAO X, CHEN ZY, KO WH, LAHER I & HUANG Y (2006) Tamoxifen dilates porcine coronary arteries: role of nitric oxide and ouabain sensitive mechanisms. British Journal of Pharmacology 149(6):703-711.

3. LEUNG HS, YAO X, LEUNG FP, KO WH, CHEN ZY, GOLLASCH M & HUANG Y (2006) Cilnidipine, a slow-acting Ca²⁺ channel blocker, induces relaxation in porcine coronary artery: role of endothelial nitric oxide and [Ca²⁺]i. British Journal of Pharmacology 147(1):55-63.

4. LEUNG HS, LEUNG FP, YAO X, KO WH, CHEN ZY, VANHOUTTE PM & HUANG Y (2006) Endothelial mediators of the acetylcholine-induced relaxation of the rat femoral arteries. Vascular Pharmacology 44(5):299-308.

5. WONG CM, YAO X, AU CL, TSANG SY, FUNG KF, LAHER I, VANHOUTTE PM & HUANG Y (2006) Raloxifene prevents endothelial function in aging ovariectomized female rats. Vascular Pharmacology 44(5):290-298.

6. LEUNG FP, YAO X, LAU CW, KO WH, LU L & HUANG Y (2005) Raloxifene relaxes rat intrarenal arteries by inhibiting Ca²⁺ influx. American Journal of Physiology – Renal Physiology 289:F137-F144.

7. CHAN YC, LEUNG FP, YAO X, LAU CW, VANHOUTTE PM & HUANG Y (2005) Raloxifene relaxes rat pulmonary arteries and veins: roles of gender, endothelium and antagonism of Ca²⁺ influx. Journal of Pharmacology and Experimental Therapeutics 312(3): 1266-1271.

8. TSANG SY, YAO X, CHAN FL, WONG CM, CHEN ZY, LAHER I & HUANG Y (2004) Estrogen and tamoxifen modulate cerebrovascular tone in ovariectomized female rats. Hypertension 44(1):78-82.

9. TSANG SY, YAO X, ESSEN K, WONG CM, CHAN FL, GOLLASCH M & HUANG Y. (2004) Raloxifene relaxes rat cerebral arteries in intro and inhibits L-type voltage-sensitive Ca²⁺ channels. Stroke 35(7):1709-1714.

10. HUANG Y, WONG CM, LAU CW, YAO, XQ, TSANG SY, SU YL & CHEN, Z.Y. (2004) Inhibition of nitric oxide/cyclic GMP-mediated relaxation by purified flavonoids, baicalin and baicalein, in rat aortic rings. Biochemical Pharmacology 67(4):787-794.

Current Grants

• RGC Earmarked Grant HK$ 1,056,000, Jan 2003- Jan 2006, CUHK 4170/02M
Mechanisms of vasorelaxation induced by the novel Ca2+ channel blocker cilnidipine and metabolites of cytochrome P450 in coronary vasculature
Principal investigator: HUANG Yu

• RGC Earmarked Grant HK$ 798,000, Oct 2003- Sept 2005, CUHK 4366/03M
Long-term Effect of Ovariectomy and Raloxifene (SERM) Replacement Therapy on Endothelial Function and on Regulation of Smooth Muscle Ion Channels
Principal investigator: HUANG Yu

• RGC Earmarked Grant HK$ 939,968, Dec 2004- June 2007, CUHK 4362/04M
Effects of Selective Estrogen Receptor Modulators on Coronary Artery Reactivity in Cholesterol-fed, Ovariectomized rabbits
Principal investigator: HUANG Yu